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Recently, a cell-permeable pan-kinase probe was shown to be effective for chemical proteomic evaluation of the kinome The XO44 kinase
To determine the selectivity profile of the inhibitors in MV4-11 and U937 cells, a chemical proteomics experiment using XO44 as a cell-permeable XO44 probe Based on lysate labeling experiments and sodium dodecyl-sulfate polyacrylamide gel electrophoresis analysis, neither alkyne
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